下列加点词的意义和用法均相同的一项是(　　)

Medicine should be placed where it is not______ to children

The bell______ the end of the period rang, ______ oue heated discussion.[ ]

234. After the 1911 Revolution, China began to use the Gregorian calendar (solar calendar) and at the same we have also used the lunar calendar(阴历) in which a leap year (闰年)______ every four years.

Her design won the first prize in the competition. Years of patience and hard work had at last ______.